Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac function during long-term hypoxemia in fetal sheep.

J G Alonso1, T Okai, L D Longo

  • 1Department of Physiology, Loma Linda University, California 92350.

The American Journal of Physiology
|August 1, 1989
PubMed
Summary

Long-term hypoxemia in fetal sheep initially maintained right ventricular function, then caused depression, followed by recovery. Ultimately, fetal right ventricular function adapted to chronic hypoxia with reduced afterload sensitivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Children with nephrotic syndrome have greater bone area but similar volumetric bone mineral density to healthy controls.

Bone·2013
Same author

Antenatal maternal hypoxic stress: adaptations of the placental renin-angiotensin system in the mouse.

Placenta·2010
Same author

Placental gene expression in a rat 'model' of placental insufficiency.

Placenta·2010
Same author

Microbiological aspects of the UK National Institute for Health and Clinical Excellence (NICE) guidance on urinary tract infection in children.

The Journal of antimicrobial chemotherapy·2010
Same author

Placental gene expression responses to maternal protein restriction in the mouse.

Placenta·2009
Same author

Detection of p53 mutations in the plasma DNA of patients with ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2004

Area of Science:

  • Cardiovascular Physiology
  • Fetal Physiology
  • Hypoxia Research

Background:

  • Prolonged hypoxemia poses risks to fetal cardiovascular development.
  • Understanding right ventricular adaptation is crucial for fetal well-being.

Purpose of the Study:

  • To investigate the impact of long-term hypoxemia on fetal right ventricular function.
  • To characterize the adaptive responses of the fetal heart to reduced oxygen levels.

Main Methods:

  • Fetal sheep were instrumented and exposed to induced hypoxemia (maternal PO2 < 60 Torr).
  • Right ventricular output and stroke volume were measured under varying preload and afterload conditions.
  • Fetal arterial pressure, heart rate, and hemoglobin were monitored.

Related Experiment Videos

Main Results:

  • Right ventricular output and stroke volume initially maintained, then depressed by 30% on day 3 of hypoxemia.
  • Fetal arterial pressure increased, and hemoglobin concentration rose by 30%.
  • Within 2 weeks, right ventricular output normalized, but sensitivity to afterload decreased.

Conclusions:

  • Fetal right ventricular function exhibits a triphasic response to prolonged hypoxemia: maintenance, depression, and recovery.
  • A new steady state is achieved with reduced afterload sensitivity, polycythemia, and hypertension.
  • These adaptations suggest a complex compensatory mechanism in the fetal cardiovascular system under chronic hypoxic stress.