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A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity

Ashok Kale1, Chiranjeevi Bingi1, Sarada Sripada2

  • 1Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.

Bioorganic & Medicinal Chemistry Letters
|September 20, 2016
PubMed

Keywords:
4-Hydroxy coumarinAryl aldehydesFuro[3,2-c]chromenesMalanonitrileN-Chlorosuccinimide

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.