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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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Related Experiment Video

Updated: Mar 14, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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A new approach to alcohol misuse.

Kerry Lyon1

  • 1Tameside Hospital NHS Foundation Trust.

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)
|September 20, 2016
PubMed
Summary

Alcohol misuse is a major preventable health issue in England, causing significant ill health and premature death. Addressing hazardous drinking is crucial to reduce the substantial burden on healthcare services.

Area of Science:

  • Public Health
  • Epidemiology
  • Health Economics

Background:

  • Alcohol misuse represents a significant public health challenge in England.
  • It is identified as the third leading preventable cause of both ill health and premature mortality.
  • The societal impact includes over a million alcohol-related hospital admissions annually.

Purpose of the Study:

  • To highlight the scale of alcohol misuse as a public health issue.
  • To quantify the economic burden of alcohol on the National Health Service (NHS).
  • To underscore the prevalence of hazardous alcohol consumption levels within the population.

Main Methods:

  • Analysis of national health statistics.
  • Review of hospital admission data related to alcohol.

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  • Economic assessment of healthcare costs attributed to alcohol.

    • Main Results:

    • Alcohol misuse is the third leading preventable cause of death and ill health.
    • Over one million hospital admissions are linked to alcohol each year.
    • The annual cost to the NHS exceeds £21 billion, with over 11 million individuals drinking at hazardous levels.

    Conclusions:

    • Urgent public health interventions are needed to combat alcohol misuse.
    • Reducing hazardous drinking can alleviate significant pressure on NHS resources.
    • The economic and health consequences necessitate targeted strategies to mitigate alcohol-related harm.