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Bioluminescent Bacterial Imaging In Vivo
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Bioengineered and biohybrid bacteria-based systems for drug delivery
Zeinab Hosseinidoust1, Babak Mostaghaci1, Oncay Yasa1
1Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart 70569, Germany.
Advanced Drug Delivery Reviews
|September 20, 2016
Summary
Bioengineered bacteria offer a promising new frontier in medical therapy as smart drug delivery agents. Genetic customization allows precise control over therapeutic functions, though challenges remain for widespread application.
Area of Science:
- Biotechnology
- Medical Microbiology
- Drug Delivery Systems
Background:
- Bacterial cell therapy has a long history, evolving from early observations in cancer patients.
- Bacterial cells possess unique characteristics making them suitable for smart drug delivery.
- Genetic manipulation allows for customization and precise control of bacterial therapeutic functions.
Purpose of the Study:
- To review the promises and challenges of using bioengineered bacteria in drug delivery.
- To introduce the biohybrid design concept as a novel paradigm in bacteria-based drug delivery.
Main Methods:
- Review of existing research on bacterial cell therapy and drug delivery.
- Analysis of genetic engineering techniques for customizing bacterial functions.
- Exploration of the biohybrid design concept for bacteria-based therapeutics.
Main Results:
- Bioengineered bacteria demonstrate potential for unique, complex therapeutic functions.
- Customization enables precise spatio-temporal control of drug delivery.
- Current systems offer advantages over traditional drug delivery methods.
Conclusions:
- Bioengineered bacteria represent a promising platform technology for advanced medical treatments.
- Significant challenges must be overcome for the clinical translation of these systems.
- The biohybrid design concept offers a new direction for bacteria-based drug delivery innovation.
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