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Updated: Mar 14, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Risk of Intussusception with Rotavirus Vaccine
Vivekanandan Kalaiselvan1, Prasad Thota1, Vipin Kumar2
1Indian Pharmacopoeia Commission, Ghaziabad, Agra, Uttar Pradesh, 201002, India.
Objective:
To study the case series for intussusception associated with the vaccination of rotavirus vaccine in children.
Methods:
The study of spontaneous adverse event monitoring such as intussusception due to rotavirus vaccine was carried out from the year 2011 through 2015. The individual case safety reports (ICSRs) of this event were collated, assessed and recorded as per the requirement of Suspected Adverse Drug Reactions Reporting form of Pharmacovigilance Programme of India (PvPI).
Results:
In the present study, 10 ICSRs of intussussception due to rotavirus vaccine were reported to PvPI. Of which 3 ICSRs were found to be causal relationship with rotavirus vaccine, as evidenced by the adequate information provided in ICSRs.
Conclusions:
Since intussusception, the emerging safety as one of the important safety concern, healthcare professionals are advised to monitor and report to the concerned authority for appropriate action.
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