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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
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[Nosocomial rotavirus gastroenteritis].

A Marinosci1, C Doit2, B Koehl3

  • 1Service de pédiatrie générale, hôpital Robert-Debré, AP-HP, 75019 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|September 20, 2016
PubMed
Summary
This summary is machine-generated.

Nosocomial rotavirus gastroenteritis (NRGE) is common in hospitalized children, particularly infants. Vaccination could reduce hospital cross-infections in vulnerable infants too young to be vaccinated.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Rotavirus is a leading cause of severe gastroenteritis in hospitalized children.
  • Nosocomial rotavirus gastroenteritis (NRGE) poses a significant risk in pediatric wards.
  • Current rotavirus vaccination is not recommended for infants in France.

Purpose of the Study:

  • To describe the characteristics and impact of NRGE in hospitalized children.
  • To assess the potential benefit of rotavirus vaccination for this population.

Main Methods:

  • Retrospective study of children hospitalized with NRGE between January 2009 and December 2013.
  • Analysis of demographic data, underlying conditions, and treatment severity.
  • Assessment of NRGE incidence and patient age in relation to vaccination eligibility.

Main Results:

  • 136 children acquired NRGE, with a stable incidence of 2.5 cases per 1000 hospitalization days.
  • Most affected children were infants (median age 7 months), often hospitalized for respiratory illness.
  • Half of the NRGE patients were under 5 months old, a group that could benefit from vaccination.

Conclusions:

  • Nosocomial rotavirus gastroenteritis is a frequent occurrence in pediatric hospitals.
  • Widespread rotavirus vaccination could decrease NRGE incidence and hospital cross-infections.
  • Vaccination indirectly protects infants too young to be vaccinated by reducing overall viral circulation.