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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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External Anatomy of the Kidney01:21

External Anatomy of the Kidney

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The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Related Experiment Video

Updated: Mar 14, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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[Autosomal polycystic kidney disease].

Frank Strutz

    Deutsche Medizinische Wochenschrift (1946)
    |September 20, 2016
    PubMed
    Summary

    Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder. Current management includes supportive care and, in select cases, tolvaptan therapy for rapid progression.

    Area of Science:

    • Nephrology
    • Medical Genetics

    Background:

    • Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic kidney disorder.
    • Disease progression and genetic associations show significant variability.
    • Recent advancements have elucidated ADPKD pathophysiology.

    Purpose of the Study:

    • To review current diagnostic and prognostic imaging techniques for ADPKD.
    • To summarize available and emerging therapeutic strategies for ADPKD management.

    Main Methods:

    • Diagnosis primarily relies on ultrasound; genetic testing is reserved for specific cases.
    • Advanced imaging like MRI and CT are crucial for assessing total kidney volume and prognosis.
    • Review of current supportive and specific therapeutic options.

    More Related Videos

    Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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    Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
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    Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

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    Related Experiment Videos

    Last Updated: Mar 14, 2026

    Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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    Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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    Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
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    Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

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    Main Results:

    • Ultrasound is highly effective for ADPKD diagnosis.
    • MRI and CT provide superior prognostic information via total kidney volume measurement.
    • Supportive care includes strict blood pressure control (<110/75 mmHg) and increased fluid intake (2.5-4 L/day).
    • Tolvaptan is a specific therapy for early-stage rapid progression, with ongoing evaluation for later stages.

    Conclusions:

    • ADPKD diagnosis is accessible via imaging, with genetic testing for select cases.
    • Prognosis is enhanced by imaging-based total kidney volume assessment.
    • Therapeutic landscape includes supportive measures and targeted therapies like tolvaptan for specific patient groups.