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Related Experiment Videos

Tissue sulfonamide concentration and correlation in turkeys.

R L Epstein1, R B Ashworth

  • 1USDA, Food Safety and Inspection Service, Chemistry Division, Washington, DC 20250.

American Journal of Veterinary Research
|June 1, 1989
PubMed
Summary

Sulfadimethoxine and sulfaquinoxaline residue levels in turkey tissues were analyzed. Serum concentrations effectively predict tissue residues, aiding in establishing safe withdrawal times for these sulfonamides.

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Area of Science:

  • Veterinary Pharmacology
  • Food Safety
  • Animal Science

Background:

  • Sulfonamides are widely used in poultry for disease treatment.
  • Understanding drug residue pharmacokinetics is crucial for food safety and regulatory compliance.
  • Establishing accurate withdrawal periods prevents violative residues in edible turkey products.

Purpose of the Study:

  • To determine sulfadimethoxine and sulfaquinoxaline concentrations in turkey serum, liver, and muscle.
  • To compare the disposition and tissue distribution of these two sulfonamides.
  • To evaluate the potential of serum concentrations as a predictor for tissue sulfonamide residues.

Main Methods:

  • Nineteen turkeys were fed diets containing either sulfadimethoxine or sulfaquinoxaline for seven days.

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  • Following medicated feed withdrawal, turkeys were sampled at intervals from 24 to 56 hours post-treatment.
  • Concentrations of sulfadimethoxine and sulfaquinoxaline were quantified in serum, liver, and skeletal muscle.

    • Main Results:

    • Serum/liver and serum/muscle ratios for sulfaquinoxaline were 60-70% higher than for sulfadimethoxine.
    • The liver/muscle ratio was consistent for both drugs (approximately 3).
    • Sulfadimethoxine exhibited a shorter half-life (approx. 16 hours) compared to sulfaquinoxaline (approx. 30 hours).
    • Low coefficients of variation (<25%) in serum/tissue ratios suggest serum is a reliable indicator of tissue residues.

    Conclusions:

    • Serum concentrations of sulfadimethoxine and sulfaquinoxaline can reliably predict tissue residue levels in turkeys.
    • The pharmacokinetic data supports the use of serum analysis for monitoring sulfonamide withdrawal periods.
    • These findings contribute to ensuring the safety of turkey meat for consumption.