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Nontargeted LC-MSn Profiling of Compounds in Ileal Fluids That Decrease after Raspberry Intake Identifies Consistent

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Raspberry consumption alters gut metabolites. Bile acid composition significantly changed in ileal fluid, with polar derivatives increasing substantially, impacting gut health insights.

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Area of Science:

  • Human Gut Physiology
  • Nutritional Biochemistry

Background:

  • Ileostomy studies offer unique insights into food digestion and gut health.
  • Previous research identified increased components, including novel triterpenoids, in ileal fluid after raspberry consumption.

Purpose of the Study:

  • To identify components consistently decreasing in ileal fluid post-raspberry supplementation.
  • To investigate alterations in bile acid metabolism in response to raspberry intake.

Main Methods:

  • Nontargeted liquid chromatography-tandem mass spectrometry (LC-MSn) analysis of ileal fluid.
  • Data deconvolution to identify and quantify metabolites.
  • Comparative analysis of pre- and post-supplementation ileal fluid samples.

Main Results:

  • 32 components significantly decreased in ileal fluid from 8 of 11 participants post-raspberry supplementation.
  • Decreased components included (poly)phenol metabolites and those linked to fat metabolism.
  • Polar glyco- and tauro-linked bile acid derivatives increased up to 100-fold, despite a reduction in some cholates.

Conclusions:

  • Raspberry consumption significantly alters the composition of ileal fluid metabolites.
  • Specific changes in bile acid profiles suggest a complex interaction between dietary components and host metabolism.
  • These findings contribute to understanding the physiological relevance of dietary phytochemicals for gut health.