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Updated: Mar 14, 2026

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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
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HiChIP: efficient and sensitive analysis of protein-directed genome architecture
Maxwell R Mumbach1,2,3, Adam J Rubin2, Ryan A Flynn1,2
1Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA.
Nature Methods
|September 20, 2016
Abstract:
Genome conformation is central to gene control but challenging to interrogate. Here we present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of conformation-informative reads by over 10-fold and lowers the input requirement over 100-fold relative to that of ChIA-PET. HiChIP of cohesin reveals multiscale genome architecture with greater signal-to-background ratios than those of in situ Hi-C.

