Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

4.4K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.4K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medicinal plant-derived nanovesicles for skin delivery: A natural biovector for therapeutics and cosmetics.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Effect of neuromuscular training strategies on injury rates in adolescent males playing sport - a systematic review and meta-analysis.

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine·2026
Same author

Cardiorespiratory fitness response to endurance training in athletes post-COVID-19 compared to unaffected athletes.

South African journal of sports medicine·2024
Same author

Kinematic differences between left- and right-handed cricket fast bowlers during the bowling action.

South African journal of sports medicine·2024
Same author

The cycle ergometer test is not a reliable alternative to the countermovement jump in the assessment of power output.

South African journal of sports medicine·2023
Same author

The core of performance in adolescent cricket pace bowlers: Trunk muscle stability, maybe, but not strength-endurance and thickness.

South African journal of sports medicine·2023
Same journal

Albumin priming enables safe and effective red blood cell exchange in low-weight children with sickle cell disease.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2026
Same journal

Catastrophic CD34+ autologous hematopoietic stem cell collection despite sustained mobilization and solutions to rescue the harvests.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2026
Same journal

Title of the study: Corrected Count Increment as a Predictor of Early Graft Dysfunction and Mortality Following Living Donor Liver Transplantation.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2026
Same journal

TLR4/MD-2 complex promotes transfusion-related acute lung injury pathogenesis through the activation of the AP-1 and NF-κB signaling pathways.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2026
Same journal

The Strategic Utility of Cryopreserved Platelets in Outer Space.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2026
Same journal

Genotyping of Human Neutrophil Antigen-3 by High Resolution Melting Analysis in Southern Thai Blood Donors.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.7K

[Feasibility study for Intercept platelets].

L Bardiaux1, S Vauzou1, B Olivier1

  • 1Établissement français du sang Pyrénées-Méditerranée, avenue de Grande-Bretagne, BP3210, 31027 Toulouse cedex 3, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|September 21, 2016
PubMed
Summary
This summary is machine-generated.

The Intercept process for platelet concentrates required some upstream adaptations but was successfully implemented. Patients receiving treated platelets received more units, though less concentrated, with stable overall platelet quantity.

Keywords:
AmotosalenConcentrés plaquettairesInterceptPlatelet concentratesTransfusion

More Related Videos

Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.8K
An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

889

Related Experiment Videos

Last Updated: Mar 14, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.7K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.8K
An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

889

Area of Science:

  • Transfusion Medicine
  • Blood Banking Technology
  • Hematology

Background:

  • Platelet transfusion therapy is critical for managing bleeding disorders.
  • Ensuring the safety and efficacy of blood products is paramount in transfusion medicine.
  • The Intercept process is a novel technology for pathogen reduction in blood components.

Purpose of the Study:

  • To evaluate the organizational impact of implementing the Intercept process on the transfusion chain.
  • To assess the transfusion outcomes for patients receiving Intercept-treated platelet concentrates.

Main Methods:

  • Observational study over 3 months at a French blood bank.
  • Analysis of organizational adaptations required for Intercept process implementation.
  • Comparison of transfusion parameters (platelet unit number, concentration, cumulative dose) between patients receiving treated and untreated platelets.

Main Results:

  • Implementation of the Intercept process required upstream adaptations and essential prior communication with healthcare institutions and physicians.
  • Patients transfused with Intercept-treated platelet concentrates received 12.9% more units.
  • These units were 12.8% less rich in platelets, but the cumulative platelet dose remained stable.

Conclusions:

  • The Intercept process can be integrated into the transfusion chain with manageable organizational adjustments.
  • While transfusion patterns changed (more units, lower concentration), the overall platelet dose delivered to patients was maintained.
  • This technology offers a viable option for enhancing blood product safety in transfusion medicine.