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Three cases of herpes zoster radiculitis in MS patients treated with natalizumab

Bassem I Yamout1, Nuhad Abou Zeid1, Ali J Taha1

  • 1Nehme and Therese Tohme Multiple Sclerosis Center, Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.

Multiple Sclerosis and Related Disorders
|September 21, 2016
PubMed

Insights

Natalizumab, a multiple sclerosis treatment, has been linked to rare herpes zoster infections in patients. Clinicians should monitor for these opportunistic infections during treatment.

Area of Science:

  • Neurology
  • Immunology

Background:

  • Natalizumab is an FDA-approved monoclonal antibody therapy for multiple sclerosis (MS).
  • While effective, natalizumab treatment carries risks of opportunistic infections, including progressive multifocal leukoencephalopathy (PML).

Observation:

  • Three cases of herpes zoster infections were observed in patients receiving natalizumab for MS.
  • Herpes zoster is a rare but serious opportunistic infection reported in patients on natalizumab therapy.

Findings:

  • The study highlights herpes zoster as a potential opportunistic infection associated with natalizumab treatment in multiple sclerosis patients.
  • These findings suggest a need for increased vigilance regarding infections during natalizumab therapy.

Implications:

  • Clinicians treating multiple sclerosis patients with natalizumab require heightened awareness of herpes zoster risks.
  • Early detection and management of opportunistic infections like herpes zoster are crucial for patient safety during natalizumab therapy.
Keywords:
Herpes zosterLebanonMiddle EastMultiple sclerosisNatalizumab

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