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Transcorporal Artificial Urinary Sphincter Cuff Placement in a Case Requiring Revision for Urethral Atrophy
Published on: June 16, 2022
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Corticosteroid Usage Is Associated With Increased Artificial Urinary Sphincter Reoperation.
Roderick Clark1, Jennifer Winick-Ng2, J Andrew McClure2
1Department of Surgery (Urology), Western University, London, ON, Canada.
Urology
|September 21, 2016
Summary
Oral corticosteroid use significantly increases the risk of artificial urinary sphincter (AUS) reoperation in men. This finding highlights a potential complication associated with corticosteroid therapy in patients with AUS devices.
Area of Science:
- Urology
- Pharmacology
- Medical Devices
Background:
- Artificial urinary sphincter (AUS) devices are used to treat urinary incontinence.
- Oral corticosteroids are commonly prescribed for various inflammatory conditions.
- Understanding potential complications of medication use in device recipients is crucial.
Purpose of the Study:
- To investigate the association between oral corticosteroid use and the risk of reoperation for artificial urinary sphincter (AUS) devices.
- To identify risk factors for AUS-related reoperations.
Main Methods:
- Retrospective cohort study using administrative data from Ontario, Canada.
- Included men aged over 65 who underwent AUS implantation between 2002 and 2013.
- Analyzed corticosteroid prescriptions and AUS reoperation rates using Cox proportional hazards models.
Main Results:
- A total of 747 men were included, with 176 (23.6%) requiring AUS reoperation.
- Corticosteroid exposure was associated with a 68% increased risk of AUS reoperation (HR: 1.68, 95% CI: 1.03-2.75).
- Radiation exposure after AUS implantation was also significantly associated with reoperation (HR: 2.07, 95% CI: 1.06-4.07).
Conclusions:
- Oral corticosteroid use presents a significant risk factor for artificial urinary sphincter reoperation.
- Clinicians should consider this increased risk when prescribing corticosteroids to patients with AUS devices.
- Further research may explore mechanisms underlying this association.
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