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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
Published on: April 21, 2016
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Recent advances in bioprinting techniques: approaches, applications and future prospects
Jipeng Li1, Mingjiao Chen1, Xianqun Fan2
1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.
Journal of Translational Medicine
|September 21, 2016
Summary
Bioprinting enables precise fabrication of tissues and organs using bioinks. This review explores inkjet, pressure-assisted, and laser-assisted bioprinting technologies, highlighting their applications and future potential in tissue engineering.
Area of Science:
- Biotechnology
- Tissue Engineering
- Regenerative Medicine
Background:
- Bioprinting is a key technology for fabricating biological structures.
- It offers high accuracy and reproducibility in tissue engineering.
- Existing bioprinting methods have distinct advantages and limitations.
Purpose of the Study:
- To review fundamental principles of major bioprinting technologies.
- To discuss recent advances in three-dimensional (3D) printing for tissue fabrication.
- To identify current challenges and future directions in the field.
Main Methods:
- Overview of inkjet-based, pressure-assisted, and laser-assisted bioprinting.
- Analysis of biomaterials, cells, and cellular microenvironment ('bioink') parameters.
- Examination of progress in printing various human tissues.
Main Results:
- Bioprinting facilitates the creation of scaffolds, cells, tissues, and organs.
- Significant advancements have been achieved in printing vasculature, heart, bone, cartilage, skin, and liver tissues.
- Biomaterial properties critically affect the quality of printed constructs.
Conclusions:
- Bioprinting technologies are rapidly evolving with diverse applications in tissue engineering.
- Overcoming current challenges is crucial for realizing the full potential of bioprinting.
- Future research should focus on refining printing techniques and bioink development for complex tissue regeneration.

