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Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
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Surgical Reconstruction for Severe Tracheal Obstruction in Morquio A Syndrome
Christian Pizarro1, Ryan R Davies1, Mary Theroux1
1Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware.
Abstract:
Progressive tracheal obstruction is commonly seen in Morquio A syndrome and can lead to life-threatening complications. Although tracheostomy can address severe upper airway obstruction, lower airway obstruction, commonly associated with a narrow thoracic inlet and vascular compression, requires an alternative approach. We describe the case of a 16-year-old patient with Morquio A syndrome whose near-fatal tracheal obstruction was relieved by timely surgical tracheal vascular reconstruction with dramatic resolution of his respiratory symptoms.
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