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Selenoprotein Gene Nomenclature.

Vadim N Gladyshev1,2, Elias S Arnér3, Marla J Berry4

  • 1From the Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, vgladyshev@rics.bwh.harvard.edu.

The Journal of Biological Chemistry
|September 21, 2016
PubMed
Summary
This summary is machine-generated.

A new nomenclature system using the root symbol "SELENO" followed by a letter has been approved for human selenoprotein genes. This system resolves naming conflicts and ensures clarity for these important redox homeostasis proteins.

Keywords:
functiongene namegenomicsnomenclatureseleniumselenocysteineselenoproteinstructure-function

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Area of Science:

  • Genetics
  • Molecular Biology
  • Biochemistry

Background:

  • The human genome encodes 25 selenoprotein genes, crucial for redox homeostasis.
  • Existing nomenclature for selenoprotein genes is often ambiguous and conflicting.
  • Selenoproteins with known functions include thioredoxin reductases, glutathione peroxidases, and iodothyronine deiodinases.

Purpose of the Study:

  • To establish a rational and coherent nomenclature system for selenoprotein-encoding genes.
  • To resolve ambiguities and conflicts in the current gene naming conventions.
  • To provide a standardized system applicable across vertebrates.

Main Methods:

  • Implementation of a new nomenclature system using the root symbol "SELENO" followed by a letter.
  • Approval of the system by the HUGO Gene Nomenclature Committee.
  • Application of the system to specific selenoprotein genes (e.g., SELENOF, SELENOH).

Main Results:

  • A standardized nomenclature (SELENO + letter) has been adopted for selenoprotein genes.
  • This system addresses previously conflicting, missing, and ambiguous gene designations.
  • The nomenclature is designed for broad applicability across vertebrate species.

Conclusions:

  • The new SELENO nomenclature provides a clear and consistent system for selenoprotein genes.
  • This standardization facilitates research and understanding of selenoprotein functions.
  • The approved system ensures accurate identification and communication regarding these vital genes.