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Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
Linfeng Xu1,2,3, Xuefeng Qiu1,2,3, Yanting Zhang2
1Department of Uroloågy, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China.
Background:
To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].
Methods:
After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy.
Results:
Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction.
Conclusions:
Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
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