Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Study of renal function by creatinine clearance].

H Arcila Herrera1, L Montero Cervantes, N Rivero Cárdenas

  • 1Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, México.

Archivos Del Instituto De Cardiologia De Mexico
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Practical aspects regarding sample size in clinical research].

Revista de gastroenterologia de Mexico·1996
Same author

[A comparison and synergy in the treatment of essential arterial hypertension].

Archivos del Instituto de Cardiologia de Mexico·1993
Same author

[Cilazapril, a new ACE inhibitor, in severe arterial hypertension].

Archivos del Instituto de Cardiologia de Mexico·1991
Same author

[Events in eclampsia. A common initial pathway].

Ginecologia y obstetricia de Mexico·1982
Same author

[Physiopathogenic focus of eclampsia].

Ginecologia y obstetricia de Mexico·1982

This study found a poor correlation between creatinine clearance and plasma creatinine levels, especially when glomerular filtration rate declines. Repeated creatinine clearance measurements are crucial for patient monitoring.

Area of Science:

  • Nephrology
  • Biochemistry

Context:

  • Creatinine is a waste product of muscle metabolism.
  • Renal clearance and plasma concentration of creatinine are key indicators of kidney function.
  • Glomerular filtration rate (GFR) significantly influences creatinine levels.

Purpose:

  • To investigate the correlation between renal clearance and plasma concentration of creatinine.
  • To analyze how different levels of glomerular filtration rate (GFR) affect creatinine levels.
  • To identify potential limitations in creatinine secretion or urinary dilution in impaired kidney function.

Summary:

  • The study observed three segments based on GFR: >60 ml/min, 30-60 ml/min, and <30 ml/min.
  • Plasma creatinine concentration increased significantly as GFR decreased, reaching up to 28 mg/dL at GFR <30 ml/min.

Related Experiment Videos

  • A poor correlation was found between creatinine clearance and plasma creatinine concentration, suggesting tubular secretion limitations or urinary dilution issues at depressed GFR.

    • Impact:

    • Highlights the limitations of using plasma creatinine concentration alone to assess kidney function.
    • Underscores the necessity of repeated creatinine clearance measurements for accurate patient follow-up.
    • Provides insights into the physiological mechanisms affecting creatinine handling by the kidneys at varying GFRs.