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Updated: Mar 14, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
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Nevi and pregnancy.

Amy Kalowitz Bieber1, Kathryn J Martires1, Marcia S Driscoll2

  • 1The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Journal of the American Academy of Dermatology
|September 21, 2016
PubMed
Summary

Pregnancy does not significantly alter moles (nevi). While skin expansion can cause growth on the breasts and abdomen, moles elsewhere show no size changes, and darkening is not supported by evidence.

Keywords:
biopsydermoscopyhistopathologymelanomamolenevipregnancy

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Area of Science:

  • Dermatology
  • Obstetrics
  • Gynecology

Background:

  • Pregnancy is often associated with changes in moles (nevi).
  • Common beliefs suggest moles may change in size or color during pregnancy.

Purpose of the Study:

  • To evaluate the physiological impact of pregnancy on melanocytic nevi.
  • To determine if pregnancy induces significant changes in mole size, color, or histology.

Main Methods:

  • Review of recent studies examining mole changes during pregnancy.
  • Analysis of data on mole size, dermoscopic findings, and histopathology in pregnant women.

Main Results:

  • Pregnancy does not cause significant physiologic changes in nevi.
  • Nevi on breasts and abdomen may enlarge due to skin expansion, but not on the back or lower extremities.
  • Insufficient evidence supports the idea that moles darken during pregnancy; transient dermoscopic changes are not indicative of melanoma.

Conclusions:

  • Changes in moles during pregnancy are often attributed to normal skin expansion rather than physiologic alterations.
  • Any histopathologic features suspicious for melanoma should be treated as such and not dismissed as pregnancy-related.
  • Biopsies of concerning moles are safe and recommended during pregnancy.