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Increased prenatal blood manganese may induce gestational blood pressure
Mohsen Vigeh1,2, Emiko Nishioka2, Kazuhito Yokoyama2
1a Department of Occupational Epidemiology , National Institute of Occupational Safety and Health , Kawasaki , Japan.
Objective:
Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined.
Methods:
To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined.
Results:
Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation. A significant association between odds of pre-hypertension with blood Mn was shown (OR:1.150, 95% CI:1.052-1.258).
Conclusion:
The current study results might suggest the blood Mn level during early stage of pregnancy as a potential risk factor for increasing the risk of gestational blood pressure.
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