Related Experiment Video

Updated: Mar 14, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

11.9K

Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs

Cui Yang1, Si-Dao Zheng2, Hong-Jin Wu3

  • 1Department of Cardiology, Huairou Hospital of Traditional Chinese Medicine, Beijing 101400, China.

Chinese Medical Journal
|September 21, 2016
PubMed
Abstract

Insights

MicroRNAs (miRNAs) regulate fibrotic processes by targeting key signaling pathways. Targeting miRNAs offers promising therapeutic strategies for fibrotic diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are crucial regulators in various biological processes.
  • Fibrosis, a pathological hallmark of many diseases, involves complex molecular signaling.
  • Dysregulation of miRNAs is implicated in the development and progression of fibrotic diseases.

Purpose of the Study:

  • To summarize recent research on the roles and mechanisms of miRNAs in regulating molecular signaling pathways in fibrosis.
  • To explore the therapeutic potential of targeting miRNAs for fibrotic diseases.

Main Methods:

  • Literature search of PubMed and Web of Science databases (2010-2015).
  • Keywords included "microRNA", "miR", "TGF-β", "MAPK", "integrin", and "fibrosis".
  • Review and analysis of selected articles on miRNA regulation of fibrotic pathways.

Main Results:

  • miRNAs regulate fibrosis by targeting substrates in immune cell sensitization, effector cell activation, and extracellular matrix remodeling.
  • Key fibrotic signaling pathways, including TGF-β, MAPK, and integrin pathways, are miRNA-regulated.
  • miRNA-mediated regulation of fibrosis occurs in multiple organs (heart, lung, liver, kidney) and influences drug actions.
  • Targeting specific miRNAs and pathways can block or reverse fibrosis, protecting organ structure and function.

Conclusions:

  • miRNAs are key regulators of molecular signaling pathways in fibrosis.
  • miRNAs represent promising therapeutic targets for novel interventions in fibrosing diseases.

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

8.1K
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.4K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

12.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K