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An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential
Feng-Pai Chou1, Chia-Tse Tsai1, Ya-Sheng Chiou1
1Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
Abstract:
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.
