Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Electro-olfactogram (EOG) in olfactometry.

M Furukawa¹, M Kamide, T Ohkado

¹Department of Otorhinolaryngology, School of Medicine, Kanazawa University, Japan.

Auris, Nasus, Larynx

|January 1, 1989

Summary

Electro-olfactogram (EOG) recordings in humans, using endoscopy, successfully identified olfactory disorders. This objective EOG method aids in differentiating olfactory epithelium versus central pathway damage in anosmia patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ.

Japanese journal of pharmacology·2001

Same author

Natural progression of untreated hepatolithiasis that shows no clinical signs at its initial presentation.

Journal of clinical gastroenterology·2001

Same author

Antitumor beta glucan from the cultured fruit body of Agaricus blazei.

Biological & pharmaceutical bulletin·2001

Same author

Simultaneous separation of common mono- and divalent cations on a zirconium-modified silica gel column by ion chromatography with non-suppressed conductimetric detection and tartaric acid-15-crown-5 as eluent.

Journal of chromatography. A·2001

Same author

Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001

Same author

Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma.

The American journal of pathology·2001

Area of Science:

Otolaryngology
Neuroscience
Sensory Physiology

Background:

The electro-olfactogram (EOG) is a potential generated by olfactory epithelium stimulation.
Previous studies demonstrated EOG in animals, but clinical application in humans faced technical challenges due to olfactory epithelium's location.

Purpose of the Study:

To ascertain the clinical application of EOG in human subjects.
To develop a method for recording EOG in humans to aid in diagnosing olfactory disorders.

Main Methods:

Utilized Olympus self-scope endoscopy for precise electrode placement in the olfactory epithelium.
Administered airborne odors via a tube while recording potentials.
Examined 22 patients with peripheral and 12 with central olfactory disorders.

Related Experiment Videos

Main Results:

Successfully recorded negative spike discharges similar to Ottoson's findings in humans.
Positive EOG rates were 28% for peripheral and 69% for central olfactory disorders.
Positive EOG rates decreased with olfactory disorder severity in chronic rhinosinusitis and were absent in anosmic cavities.

Conclusions:

EOG recording in humans is feasible and provides objective findings.
EOG is a valuable tool for the differential diagnosis of anosmia.
This method helps distinguish between olfactory epithelium disorders and central olfactory tract damage.