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Liver and Muscle Contribute Differently to the Plasma Acylcarnitine Pool During Fasting and Exercise in Humans

G Xu1, J S Hansen1, X J Zhao1

  • 1Key Laboratory of Separation Science for Analytical Chemistry (G.X., X.J.Z., X.L.W.), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Department of Clinical Biochemistry (J.S.H., P.P.), Rigshospitalet, Copenhagen, Denmark; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research (J.S.H., B.K.P., P.P.), Department of Infectious Diseases and CMRC, Rigshospitalet, Copenhagen, Denmark; Department of General Surgery and Laboratory of General Surgery (S.C.), Xinhua Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Biliary Tract Diseases Research (S.C.), Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Endocrinology (M.H., H.U.H., R.L., C.W.), Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine IV, University Tuebingen, Germany; Department of Hepatology (J.O.C.), Rigshospitalet, Copenhagen, Denmark; Department of Anaesthesiology (N.H.S.), The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the University of Tuebingen (H.U.H., R.L., C.W.), Tuebingen, Germany; and German Center for Diabetes Research (H.U.H., R.L., C.W.), Germany.

The Journal of Clinical Endocrinology and Metabolism
|September 21, 2016
PubMed
Summary

Plasma acylcarnitine levels change with fasting and exercise. The liver releases short-chain acylcarnitines, while muscles release medium-chain acylcarnitines during exercise, contributing to systemic levels.

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