Related Experiment Video
Updated: Mar 14, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
DengueME: A Tool for the Modeling and Simulation of Dengue Spatiotemporal Dynamics
Tiago França Melo de Lima1, Raquel Martins Lana2, Tiago Garcia de Senna Carneiro3
1Departamento de Computação e Sistemas (DECSI), Instituto de Ciências Exatas e Aplicadas (ICEA), Universidade Federal de Ouro Preto (UFOP) - Campus João Monlevade, João Monlevade, MG 35931-008, Brasil. tiagolima@decsi.ufop.br.
Abstract:
The prevention and control of dengue are great public health challenges for many countries, particularly since 2015, as other arboviruses have been observed to interact significantly with dengue virus. Different approaches and methodologies have been proposed and discussed by the research community. An important tool widely used is modeling and simulation, which help us to understand epidemic dynamics and create scenarios to support planning and decision making processes. With this aim, we proposed and developed DengueME, a collaborative open source platform to simulate dengue disease and its vector's dynamics. It supports compartmental and individual-based models, implemented over a GIS database, that represent Aedes aegypti population dynamics, human demography, human mobility, urban landscape and dengue transmission mediated by human and mosquito encounters. A user-friendly graphical interface was developed to facilitate model configuration and data input, and a library of models was developed to support teaching-learning activities. DengueME was applied in study cases and evaluated by specialists. Other improvements will be made in future work, to enhance its extensibility and usability.
Related Concept Videos
Modeling with Differential Equations
Steps in Outbreak Investigation
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Pharmacodynamic Models: Overview
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model

