Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

2.7K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.7K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.3K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.3K
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

1.1K
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
1.1K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.3K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.3K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

914
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
914
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

2.4K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Unit-Dosing of Sunscreen on Adherence at Golf Tournaments.

Journal of cutaneous medicine and surgery·2022
Same author

Adherence to levetiracetam for management of epilepsy: Assessment with electronic monitors.

Seizure·2021
Same author

Acantholytic anaplastic extramammary paget disease.

Cutis·2019
Same author

The complexity of adverse event assessment and counseling for patients on biologic treatment.

Expert review of clinical immunology·2019
Same author

An Evidence-Based Evaluation of Disclosure.

The Journal of dermatological treatment·2019
Same author

Choice Overload in Systemic Psoriasis Therapy.

The Journal of dermatological treatment·2019

Related Experiment Video

Updated: Mar 14, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K

Compounded Topical Analgesics for Chronic Pain.

Abigail E Cline1, Jake E Turrentine

  • 1From the *Medical College of Georgia, and †Division of Dermatology, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA.

Dermatitis : Contact, Atopic, Occupational, Drug
|September 21, 2016
PubMed
Summary
This summary is machine-generated.

Topical analgesic medications offer benefits for chronic pain management, including fewer systemic side effects. Dermatologists should anticipate increased cases of contact dermatitis due to rising use of these compounded topical pain relievers.

More Related Videos

Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

10.0K
Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding
02:41

Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding

Published on: May 3, 2024

2.4K

Related Experiment Videos

Last Updated: Mar 14, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K
Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

10.0K
Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding
02:41

Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding

Published on: May 3, 2024

2.4K

Area of Science:

  • Pharmacology and Dermatology
  • Pain Management

Background:

  • Topical analgesic medications are increasingly utilized for chronic pain.
  • These formulations offer advantages such as reduced systemic side effects, improved patient compliance, and direct target site access.

Purpose of the Study:

  • To review the mechanisms, adverse effects, and evidence for commonly used medications in compounded topical pain formulations.
  • To inform dermatologists about the potential for increased irritant and allergic contact dermatitis.

Main Methods:

  • Literature review of commonly used analgesic medications in topical compounds.
  • Analysis of mechanisms of action, adverse effects, and clinical evidence.
  • Discussion of dermatological implications.

Main Results:

  • Compounded topical medications often combine 3+ agents for complementary effects at lower individual doses.
  • Key medications used in these compounds are reviewed for efficacy and safety.
  • Increased use correlates with a higher incidence of contact dermatitis.

Conclusions:

  • Compounded topical analgesics provide a viable option for chronic pain management.
  • Dermatologists must be prepared for an increase in contact dermatitis cases associated with these treatments.