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Updated: Mar 14, 2026

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Published on: May 19, 2022
Female sexual dysfunction post radical cystectomy and urinary diversion
M H Zahran1, O Fahmy2,3, A S El-Hefnawy1
1a Urology and Nephrology Center , Mansoura University , Egypt.
Radical cystectomy and urinary diversion significantly impact female sexual function, with loss of sexual desire and orgasm disorders being most common. Nerve-sparing techniques may reduce sexual dysfunction incidence.
Area of Science:
- Urology
- Oncology
- Sexual Medicine
Background:
- Radical cystectomy (RC) and urinary diversion (UD) are standard treatments for bladder cancer.
- Female sexual function (FSF) is a crucial component of health-related quality of life (HRQoL) post-RC.
- Limited data exists on the specific impact of RC and UD on FSF.
Purpose of the Study:
- To systematically review the literature on the impact of RC and UD on FSF.
- To identify common female sexual dysfunctions (FSD) post-RC.
- To explore factors associated with FSD and its recovery.
Main Methods:
- A systematic literature search was performed using Medline (1980-2016) adhering to PRISMA guidelines.
- Included studies focused on FSF assessment after RC and UD.
- Data extraction and critical analysis of 11 eligible studies involving 361 women.
Main Results:
- Loss of sexual desire (49%) and orgasm disorders (39%) were the most prevalent FSDs.
- Dyspareunia (25%) and vaginal lubrication disorders (9.5%) were also reported.
- Incidence of FSD was significantly lower with genital-/nerve-sparing RC (10%) versus conventional RC (59%).
Conclusions:
- FSF is a vital aspect of HRQoL after RC and UD.
- Current literature is insufficient to provide comprehensive guidance for surgeons and patients.
- Further research is needed to better understand and manage FSD post-RC.
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