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Related Experiment Video

Updated: Mar 14, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Neonatal mucosal immunology.

N Torow¹, B J Marsland², M W Hornef¹

¹Institute of Medical Microbiology, RWTH University Hospital Aachen, Aachen, Germany.

Mucosal Immunology

|September 22, 2016

Summary

Newborns

Area of Science:

Immunology
Microbiology
Neonatal Development

Background:

Neonatal mucosal barriers face significant environmental, nutritional, and microbial exposures post-birth.
The developing immune system and the establishment of the microbiome occur concurrently in neonates.

Purpose of the Study:

To review the critical role of microbes in immune maturation within the gut and lung.
To highlight how early microbial interactions shape long-term immune characteristics and disease trajectories.

Main Methods:

This review synthesizes current research on neonatal immune development and microbiome establishment.
Focuses on the interplay between microbial exposures and immune system maturation in the gastrointestinal and respiratory tracts.

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Related Experiment Videos

Last Updated: Mar 14, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Main Results:

Early microbial exposures are key determinants of immune tone at mucosal barriers.
The timing and nature of host-microbe interactions influence immune system development and health outcomes.

Conclusions:

Microbes play a central role in the maturation of the neonatal gut and lung immune systems.
Understanding these interactions offers potential targets for future therapeutic interventions to promote immune health.