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Psoriatic arthritis in children
T R Southwood1, R E Petty, P N Malleson
1Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Arthritis and Rheumatism
|August 1, 1989
Summary
A new definition identified juvenile psoriatic arthritis (JPsA) in 35 children. This research suggests JPsA shares more similarities with juvenile rheumatoid arthritis than previously thought.
Area of Science:
- Pediatrics
- Rheumatology
- Immunology
Background:
- Juvenile psoriatic arthritis (JPsA) is a challenging diagnosis.
- A clear definition is needed for accurate identification and research.
Purpose of the Study:
- To evaluate a proposed definition for identifying definite or probable JPsA in children.
- To compare the clinical and immunological features of JPsA with other pediatric rheumatic diseases.
Main Methods:
- A cohort of 35 children was assessed using a proposed JPsA definition.
- Criteria included arthritis, psoriatic rash, dactylitis, nail pitting, and family history.
- Immunological markers (ANA, anticollagen antibodies, HLA-DR) were analyzed.
Main Results:
- The definition identified 24 definite and 11 probable JPsA cases.
- Most cases (33/35) presented with pauciarticular onset but evolved to polyarticular disease (23/35).
- Frequencies of uveitis, ANA, anticollagen antibodies, and HLA-DR were similar to juvenile rheumatoid arthritis.
Conclusions:
- The proposed definition effectively identifies JPsA in children.
- JPsA appears to have significant clinical and immunological overlap with juvenile rheumatoid arthritis.
- This finding challenges the traditional classification of JPsA within seronegative spondylarthropathies.