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Updated: Mar 14, 2026
07:11
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and
Thomas M Gorter1, Elke S Hoendermis1, Dirk J van Veldhuisen1
1Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
European Journal of Heart Failure
|September 22, 2016
Summary
Right ventricular dysfunction and pulmonary hypertension are common in heart failure with preserved ejection fraction (HFpEF). Both conditions are linked to increased mortality risk in HFpEF patients.
Area of Science:
- Cardiology
- Pulmonology
- Heart Failure Research
Background:
- Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are increasingly recognized in heart failure with preserved ejection fraction (HFpEF).
- The prevalence and prognostic implications of RV dysfunction in HFpEF have been reported with significant variability.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence and prognostic value of RV dysfunction and PH in HFpEF.
- To quantify the association between RV dysfunction, PH, and mortality in HFpEF patients.
Main Methods:
- Systematic review and meta-analysis of English literature up to May 2016.
- Evaluation of studies using defined criteria for RV dysfunction (TAPSE, FAC, RV S') and PH (MPAP, PASP).
- Calculation of combined hazard ratios (HRs) for mortality outcomes.
Main Results:
- Prevalence of RV dysfunction was 28% (TAPSE), 18% (FAC), and 21% (RV S') in studies with stringent HFpEF criteria.
- Prevalence of PH was 68% for both increased MPAP and PASP.
- TAPSE, FAC, MPAP, and PASP were all significantly associated with increased mortality risk.
Conclusions:
- RV dysfunction and PH are highly prevalent in HFpEF.
- Both RV dysfunction and PH are independently associated with a poor prognosis and increased mortality in HFpEF patients.
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