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An Acute Ocfentanil Fatality: A Case Report with Postmortem Concentrations.

F E Dussy1, S Hangartner2, C Hamberg2

  • 1Forensic Chemistry and Toxicology, Institute of Legal Medicine of the University of Basel, Pestalozzistrasse 22, CH-4056 Basel, Switzerland franz.dussy@bs.ch.

Journal of Analytical Toxicology
|September 22, 2016
PubMed
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This summary is machine-generated.

A fatal overdose case was linked to ocfentanil, a potent synthetic opioid. Forensic toxicology confirmed its presence in the deceased and seized substances, highlighting the dangers of illicit drug use.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Pharmacology

Background:

  • A suspicious death prompted an investigation into potential drug intoxication.
  • Initial assumptions focused on heroin, necessitating comprehensive toxicological analysis.

Observation:

  • Ocfentanil was detected in the deceased's urine and in a brown powder found at the scene.
  • The seized powder contained 0.91% ocfentanil.
  • Ocfentanil concentrations were measured in peripheral blood (9.1 µg/L), heart blood (27.9 µg/L), and urine (480 µg/L).

Findings:

  • The study details four methods for determining ocfentanil concentrations in blood.
  • Concurrent use of citalopram, quetiapine, and cannabinoids was identified in the deceased's system.

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Implications:

  • This case underscores the critical role of advanced toxicological screening in identifying novel synthetic opioids.
  • Accurate quantification of ocfentanil and co-administered substances is crucial for forensic investigations and understanding overdose dynamics.
  • The findings highlight the evolving landscape of illicit drug markets and the need for ongoing forensic analysis.