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Chronic Bowel Disorders: Introduction01:17

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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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Chronic systemic inflammation originating from epithelial tissues.

Özge Uluçkan1, Erwin F Wagner1

  • 1Genes, Development and Disease Group, Cancer Cell Biology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

The FEBS Journal
|September 22, 2016
PubMed
Summary
This summary is machine-generated.

Chronic systemic inflammation (CSI) contributes to major diseases. This review highlights how CSI from epithelial tissues, like skin, impacts organ systems and causes comorbidities, including bone loss.

Keywords:
bone losschronic systemic inflammationcomorbiditiesgutinflammatory bowel diseasemicrobiotapsoriasisskin

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Area of Science:

  • Immunology
  • Pathophysiology
  • Endocrinology

Background:

  • Chronic systemic inflammation (CSI) is increasingly recognized as a key factor in diverse diseases, including cancer, metabolic disorders, and neurological conditions.
  • Genetically engineered mouse models have advanced the study of CSI's molecular mechanisms.
  • The concept of organ cross-talk driven by CSI is gaining traction in understanding disease pathogenesis.

Purpose of the Study:

  • To review whole-organism physiology concerning CSI originating from epithelial tissues (skin, gut).
  • To discuss mechanisms, immune cells, and molecules driving comorbidities associated with CSI.
  • To emphasize recent findings linking skin inflammation to bone loss.

Main Methods:

  • Review of existing literature on chronic systemic inflammation and its effects.
  • Analysis of genetically engineered mouse models for inflammatory diseases.
  • Focus on organ cross-talk and specific disease examples like psoriasis, atopic dermatitis, and inflammatory bowel disease.

Main Results:

  • CSI originating from epithelial tissues significantly impacts systemic health.
  • Specific immune cells and molecules mediate common comorbidities (cardiovascular, metabolic, neurological, bone loss).
  • Skin inflammation is directly linked to bone loss, a significant comorbidity.

Conclusions:

  • Understanding CSI's impact on organ cross-talk is crucial for managing complex diseases.
  • Targeting inflammatory pathways may offer therapeutic strategies for associated comorbidities.
  • Further research into the skin-bone axis in CSI is warranted.