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Total thyroidectomy: a clue to understanding the metabolic changes induced by subclinical hyperthyroidism?
Pierre Bel Lassen1, Aglaia Kyrilli1, Maria Lytrivi1
1Department of Endocrinology, Université Libre de Bruxelles, Brussels, Belgium.
Clinical Endocrinology
|September 22, 2016
Summary
Subclinical hyperthyroidism (eSCH) significantly increases BMI and LDL cholesterol after thyroidectomy. Correcting eSCH appears to directly impact weight and lipid metabolism, suggesting its role in these processes.
Area of Science:
- Endocrinology
- Metabolic Research
- Thyroidology
Background:
- Endogenous subclinical hyperthyroidism (eSCH) is known to affect heart and bone health.
- Limited data exist on eSCH's impact on weight regulation and lipid metabolism.
Purpose of the Study:
- To evaluate changes in body weight and metabolic parameters after total thyroidectomy.
- To compare patients with pre-operative eSCH to pre-operative euthyroid (EUT) patients.
Main Methods:
- Retrospective study of 225 patients undergoing total thyroidectomy for benign multinodular goitre.
- Patients were divided into eSCH (n=74) and EUT (n=151) groups with a mean follow-up of 26.1 months.
Main Results:
- The eSCH group showed a significantly greater absolute BMI gain (1.11 kg/m²) compared to the EUT group (0.33 kg/m²).
- A significant increase in LDL cholesterol was observed in the eSCH group (16.1 mg/dl), but not in the EUT group.
- Pre-operative TSH levels were the primary factor associated with increased BMI and LDL cholesterol.
Conclusions:
- Total thyroidectomy led to increased weight and serum cholesterol in the eSCH group.
- These findings suggest a direct effect of eSCH on body weight regulation and lipid metabolism.
- Post-operative TSH levels were similar, supporting the conclusion that eSCH correction influences these metabolic changes.
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