Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholinergic Neurons: Neurotransmission01:23

Cholinergic Neurons: Neurotransmission

5.9K
Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...
5.9K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

793
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
793
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.8K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.8K
Epigenetic Regulation01:46

Epigenetic Regulation

34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
Epigenetic Regulation01:37

Epigenetic Regulation

4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.1K
Epigenetic Regulation01:46

Epigenetic Regulation

26.2K
26.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Correction to: Recent Structural Insights into the Molecular Architecture of Synapses.

Advances in neurobiology·2026
Same journal

Roles of Glia in Synapse Nano-organization.

Advances in neurobiology·2026
Same journal

Visualizing Postsynaptic Density in Excitatory Synapses with Electron Tomography.

Advances in neurobiology·2026
Same journal

Optical Approaches to Dissect the Structure and Dynamics of the Synapse at Nanoscale Resolution.

Advances in neurobiology·2026
Same journal

Functional Nano-segregation of Distinct Forms of Neurotransmission.

Advances in neurobiology·2026
Same journal

Scales of Postsynaptic Nanostructure: Molecules, Nanoclusters, and Nanodomains.

Advances in neurobiology·2026

Related Experiment Video

Updated: Mar 14, 2026

A Chromatin Assay for Human Brain Tissue
11:31

A Chromatin Assay for Human Brain Tissue

Published on: March 21, 2008

13.5K

Choline and the Brain: An Epigenetic Perspective.

Rola Aldana Bekdash1

  • 1Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA. rola.bekdash@gmail.com.

Advances in Neurobiology
|September 22, 2016
PubMed
Summary

Choline is essential for brain development and function. Adequate choline intake may protect against neurodegenerative disorders and support memory throughout life by influencing epigenetic mechanisms.

Keywords:
BrainCholineEnvironmentEpigeneticsGeneMemoryNeurodegenerative diseases

More Related Videos

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

834
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

8.0K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Chromatin Assay for Human Brain Tissue
11:31

A Chromatin Assay for Human Brain Tissue

Published on: March 21, 2008

13.5K
Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

834
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

8.0K

Area of Science:

  • Neuroscience
  • Epigenetics
  • Nutritional Science

Background:

  • Choline is vital for brain development, methylation (epigenetic regulation), membrane integrity, and neurotransmission.
  • Environmental factors and diet can induce epigenetic changes affecting neuronal gene expression and brain function.
  • Choline acts as an epigenetic modifier, influencing DNA methylation, gene expression, and cellular function.

Purpose of the Study:

  • To explore the impact of choline-gene interactions on brain function across the lifespan.
  • To highlight choline's potential as a neuroprotectant against neurodegenerative disorders.
  • To examine choline's role in maintaining mental health.

Main Methods:

  • Review of existing literature on choline's role in brain development and function.
  • Analysis of choline's involvement in epigenetic mechanisms like DNA and histone methylation.
  • Examination of studies on choline's effects on memory and neuroprotection.

Main Results:

  • Abnormal choline levels in early life can impair adult memory functions and contribute to stress-related disorders.
  • Perinatal choline supplementation in rodent models enhances adult memory performance.
  • Choline influences S-adenosylmethionine synthesis, a key methyl donor for epigenetic modifications.

Conclusions:

  • Choline plays a critical role in regulating gene expression and brain function through epigenetic pathways.
  • Maintaining adequate choline levels is crucial for cognitive health and may mitigate age-related memory decline.
  • Choline shows promise as a neuroprotective agent for mental health across the lifespan.