Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats
Yedy Israel1, Fernando Ezquer2, María Elena Quintanilla3
1Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile yisrael@uchile.cl yedy.israel@vtr.net.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|September 22, 2016
Abstract:
Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.
