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Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks

Goodwin G Jinesh1, Sharada Mokkapati2, Keyi Zhu2

  • 1Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA. goodwinjinesh@gmail.com.

Apoptosis : an International Journal on Programmed Cell Death
|September 22, 2016
PubMed

Insights

Pim kinases are crucial in cancer development, promoting tumor growth and protecting cancer cells from therapy and immune responses. Understanding their regulation is key to developing new cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Pim kinases are increasingly recognized for their role in oncogenesis.
  • They regulate key cellular processes including apoptosis, immune evasion, and tumorigenesis.

Purpose of the Study:

  • To review the regulation and expression of Pim kinases in cancer.
  • To elucidate the mechanisms by which Pim kinases protect cancer cells from therapeutic and immune attacks.
  • To highlight the contribution of Pim kinases to tumorigenesis, cellular transformation, and glycolysis.

Main Methods:

  • Literature review focusing on Pim kinase regulation and function in cancer.
  • Analysis of studies detailing Pim kinase roles in apoptosis, immune evasion, and therapeutic resistance.
  • Examination of research on Pim kinase involvement in cellular transformation and metabolic reprogramming.

Main Results:

  • Pim kinases maintain their expression during apoptosis and cellular transformation.
  • They protect mitochondria from apoptotic damage and defend cancer cells against immune surveillance.
  • Pim kinases confer resistance to therapeutic interventions and influence cancer cell metabolism, including glycolysis.

Conclusions:

  • Pim kinases are vital regulators of multiple cancer hallmarks, including uncontrolled proliferation and survival.
  • Their multifaceted roles in evading apoptosis, immune attack, and therapeutic strategies underscore their significance in cancer progression.
  • Targeting Pim kinases presents a promising avenue for novel cancer therapies, particularly in combating cancer stem cells.
Keywords:
BlebbishieldsCXCR4MitochondriaP-glycoproteinROSVEGF

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