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[Multiple organ failure syndrome: correlation of mortality and the Modified Criteria for Multiple Organ Failure]
Abstract:
Seventy-two patients from one month to 15 years of age that according with the Modificated criterion of multiple organ failure (MCMOF) had two or more organ failures were studied. They were divided into two groups: Group I consisted of 55 patients that survived and group II of 17 patients that died. In both groups, the MCMOF was determinated upon admission and discharge, as well as the maximum obtained during the evolution. The comparison of both groups, with respect to the number of organic failures presented and the points of MCMOF showed highly significant differences with p less than 0.001, found in group I: 1.27 +/- 0.96 organ failures and a value of 4.84 +/- 2.92 of the MCMOF and in the group II: 3.84 +/- 1.59 organ failures and 25.68 +/- 7.57 points of the MCMOF respectively. The comparison between the number of organic failures at admission and discharge showed significant differences in both groups, having the tendency to decrease in group I from 1.87 +/- 1.01 to 0.56 +/- 0.60 and in the group II to increase from 3.41 +/- 1.46 to 4.35 +/- 1.45. The same phenomenon was observed for the values of the MCMOF with a qualification of 7.72 +/- 5.36 to 1.87 +/- 1.82 in a group I and from 18.94 +/- 10.31 to 33.38 +/- 8.27 in group II. Spearman correlation coeficient between the number of organic failures and values of the MCMOF showed and r = 0.99 and equivalent p less than 0.001, highly significant.
Insights
The Modificated Criterion of Multiple Organ Failure (MCMOF) score effectively differentiates pediatric survivors from non-survivors. Higher MCMOF scores and more organ failures at admission predict mortality in critically ill children.
Area of Science:
- Pediatric critical care medicine
- Multisystem organ failure research
Background:
- Multiple organ failure (MOF) is a leading cause of mortality in critically ill children.
- Accurate prognostic tools are essential for managing pediatric MOF.
- The Modificated Criterion of Multiple Organ Failure (MCMOF) score is a potential indicator for pediatric MOF outcomes.
Purpose of the Study:
- To evaluate the effectiveness of the MCMOF score in predicting mortality in pediatric patients with multiple organ failures.
- To compare MCMOF scores and the number of organ failures between survivors and non-survivors.
Main Methods:
- A retrospective study of 72 pediatric patients (1 month to 15 years) diagnosed with MOF using the MCMOF criteria.
- Patients were divided into two groups: survivors (Group I, n=55) and non-survivors (Group II, n=17).
- MCMOF scores and the number of organ failures were assessed at admission, discharge, and peak during hospitalization.
Main Results:
- Significant differences (p<0.001) were observed in the number of organ failures and MCMOF scores between survivors and non-survivors.
- Group I (survivors) had fewer organ failures (1.27±0.96) and lower MCMOF scores (4.84±2.92) compared to Group II (non-survivors) (3.84±1.59 and 25.68±7.57, respectively).
- Organ failures and MCMOF scores decreased in survivors but increased in non-survivors from admission to discharge, with a strong correlation (r=0.99, p<0.001) between organ failures and MCMOF scores.
Conclusions:
- The MCMOF score is a highly sensitive and specific tool for predicting mortality in pediatric patients with multiple organ failure.
- Admission MCMOF scores and the number of organ failures are critical determinants of survival in critically ill children.
- The dynamic changes in MCMOF scores and organ failure counts during hospitalization offer further prognostic insights.