Acquisition of classical conditioning without cerebellar cortex

The left cerebellar cortex was surgically aspirated in rabbits who were then subsequently trained for classical conditioning of the nictitating membrane. All rabbits were trained sequentially on both eyes. Rabbits with the lesion confined to the cerebellar cortex were able to learn with the eye ipsilateral to the lesion although it took many times longer than reported for either naive rabbits or for rabbits first trained on the unlesioned, contralateral side. Rabbits with lesions that included the cerebellar cortex and the cerebellar interpositus nucleus did not learn with the eye ipsilateral to the lesion. Learning with the eye contralateral to either type of lesion was always very rapid. It is now clear on the basis of this and previous studies that cerebellar cortex, unlike the cerebellar interpositus nucleus, is not essential for acquisition or relearning/retention of classical conditioning. However, cerebellar cortex normally plays an important role since acquisition of classical eyeblink conditioning is prolonged and of poor quality in its absence.