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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Related Experiment Video

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Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
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Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy.

Irina Arutyunyan1, Andrey Elchaninov2, Andrey Makarov1

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Human umbilical cord mesenchymal stem cells show promising properties for transplantation. Further research requires specialized biobanking and standardized criteria for successful clinical application.

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Immunology

Background:

  • Mesenchymal stem cells (MSCs) are crucial in regenerative medicine.
  • Human umbilical cord (hUC) is a rich source of MSCs.
  • Understanding hUC-MSC properties is vital for therapeutic development.

Purpose of the Study:

  • To review the properties of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs).
  • To analyze preclinical and clinical studies involving hUC-MSCs.
  • To discuss the future prospects and challenges of hUC-MSC transplantation.

Main Methods:

  • Comprehensive literature review of preclinical studies.
  • Systematic review of clinical trials.
  • Analysis of cell properties including origin, proliferation, plasticity, stability, transcriptome, secretome, and immunomodulatory activity.

Main Results:

  • hUC-MSCs exhibit significant proliferative potential and immunomodulatory functions.
  • Evidence supports the stability of karyotype and phenotype in hUC-MSCs.
  • Preclinical and clinical data indicate therapeutic potential but highlight variability.

Conclusions:

  • hUC-MSCs possess a favorable profile for cell-based therapies.
  • Standardization of biobanking and transplant protocols is essential for clinical translation.
  • Optimized biobanking and standardized criteria are needed for widespread hUC-MSC application.