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Related Experiment Videos

Single punch, double biopsy.

Malte Krönig1, Norbert Nanko2, Vanessa Drendel3

  • 1Department of Urology, University of Freiburg Medical Centre, Hugstetter Strasse 55, 79106 Freiburg, Germany.

Springerplus
|September 22, 2016
PubMed
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A novel biopsy needle system yields two tissue cores simultaneously from a single biopsy. This innovation enables concurrent histopathologic diagnosis and molecular analysis from limited cancer samples.

Area of Science:

  • Oncology
  • Pathology
  • Biotechnology

Background:

  • Biopsy material is crucial for diagnosing and analyzing lethal metastatic prostate cancer.
  • Limited tissue quantity from biopsies restricts simultaneous molecular marker analysis and histopathologic evaluation.
  • Single-cell analytics offer in-depth tumor characterization from minimal tissue samples.

Purpose of the Study:

  • To develop an innovative biopsy needle capable of generating two distinct tissue cores from a single biopsy.
  • To facilitate simultaneous standard histopathologic analysis and single-cell analytics from the same biopsy event.

Main Methods:

  • Modification of a conventional punch biopsy needle by milling two parallel longitudinal rifts.
  • Separation of the rifts by a 100 µm thick metal sheet, allowing each rift to hold a single tissue core.
Keywords:
Needle biopsyPrimary tissueProstate cancerSingle cellTissue heterogeneity

Related Experiment Videos

  • Generation of dual cores from a single biopsy event for parallel analyses.

    • Main Results:

    • Reproducible generation of two tissue cores from a single biopsy using the modified needle.
    • Congruent histopathologic analysis results from both generated cores.
    • Sufficient material obtained from both cores for standard Hematoxylin and Eosin (H&E) staining and histopathological evaluation.

    Conclusions:

    • The modified biopsy system enables simultaneous acquisition of tissue cores for both diagnostic and scientific purposes.
    • This approach is applicable to solid tumors and metastatic sites, maximizing information from minimal tissue.
    • Facilitates integrated diagnostic and molecular profiling from a single biopsy procedure.