The pathophysiology of acquired premature ejaculation

Area of Science:

• Urology
• Sexual Medicine
• Andrology

Background:

• Premature ejaculation (PE) is a common male sexual dysfunction.
• Acquired PE specifically develops after a period of normal ejaculatory function.
• The International Society for Sexual Medicine (ISSM) has provided definitions for PE.

Purpose of the Study:

• To define acquired premature ejaculation (PE) based on the ISSM criteria.
• To explore the etiological factors and clinical characteristics associated with acquired PE.

Main Methods:

• Review of literature on acquired premature ejaculation.
• Analysis of the ISSM's second Ad Hoc Committee's definition and findings.
• Comparison of acquired PE with other forms of PE.

Main Results:

• Acquired PE is characterized by a rapid reduction in ejaculation latency (approx. 3 minutes or less).
• Key features include inability to delay ejaculation and negative personal consequences (distress, avoidance).
• Common causes include sexual performance anxiety, erectile dysfunction (ED), and psychological/relationship issues.

Conclusions:

• Acquired PE is a distinct clinical entity with identifiable causes and consequences.
• Men with acquired PE are often older and present with comorbidities like hypertension, diabetes, and ED.
• Understanding the etiology is crucial for effective management of acquired PE.