Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

25.5K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
25.5K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.4K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.4K
Sperm Transport01:15

Sperm Transport

4.4K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
4.4K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

3.3K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.3K
Infertility in Males01:23

Infertility in Males

652
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
652
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

682
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
682

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Penile size in adult men-recommendations for clinical and research measurements.

International journal of impotence research·2019
Same author

Long-term biochemical progression-free survival following brachytherapy for prostate cancer: Further insight into the role of short-term androgen deprivation and intermediate risk group subclassification.

PloS one·2019
Same author

Comparison between preoperative and real-time intraoperative planning ¹²⁵I permanent prostate brachytherapy: long-term clinical biochemical outcome.

Radiation oncology (London, England)·2013
Same author

High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound-guided template saturation biopsy.

BJU international·2012
Same author

Validation and comparison of the two Kattan nomograms in patients with prostate cancer treated with (125) iodine brachytherapy.

BJU international·2011
Same author

The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation.

The journal of sexual medicine·2011

Related Experiment Video

Updated: Mar 14, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.2K

The pathophysiology of delayed ejaculation.

Juza Chen1

  • 1Department of Urology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 6423906, Israel.

Translational Andrology and Urology
|September 22, 2016
PubMed
Summary

Delayed ejaculation (DE), a male sexual dysfunction affecting 1-4% of men, has a complex pathophysiology involving biological and psychological factors. Further research is needed to fully understand its causes and improve treatment strategies.

Keywords:
Ejaculatory dysfunction (EjD)climaxdelayed ejaculation (DE)inhibited ejaculationretarded ejaculationsexual dysfunction

More Related Videos

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

5.1K
Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

1.8K

Related Experiment Videos

Last Updated: Mar 14, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.2K
Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

5.1K
Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

1.8K

Area of Science:

  • Male Sexual Health
  • Urology
  • Neuroscience

Background:

  • Delayed ejaculation (DE) is a poorly understood male sexual dysfunction with a prevalence of 1-4%.
  • Its pathophysiology is multifactorial, encompassing psychosexual, behavioral, cultural, neurochemical, and psychosocial elements.
  • Despite advances, a comprehensive understanding of DE's causes remains limited.

Purpose of the Study:

  • To systematically review and update the current knowledge on the pathophysiology of delayed ejaculation.
  • To consolidate information on the epidemiology and prevalence of DE.

Main Methods:

  • A systematic review of Medline and PubMed databases was conducted.
  • Searched for publications on ejaculatory dysfunction (EjD), DE, retarded ejaculation, inhibited ejaculation, and climax from 1960 to 2015.
  • 105 relevant articles were selected from 178 initially identified.

Main Results:

  • The pathophysiology of DE involves interconnected cerebral sensory areas, motor centers, and spinal nuclei.
  • Biogenic, psychogenic, and other factors significantly influence DE.
  • Despite numerous publications, dedicated research on DE pathophysiology remains scarce.

Conclusions:

  • Delayed ejaculation has a complex pathophysiology involving central and peripheral nervous system pathways.
  • Biogenic and psychogenic factors play crucial roles in the development of DE.
  • Further dedicated research is essential to elucidate the mechanisms underlying DE.