Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Post orgasmic illness syndrome (POIS).

Marcel D Waldinger1

  • 1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA;; Private Practice of Psychiatry and Neurosexology, Amstelveen, The Netherlands.

Translational Andrology and Urology
|September 22, 2016
PubMed
Summary

Post Orgasmic Illness Syndrome (POIS) is a debilitating autoimmune condition causing post-ejaculatory illness in men. Research suggests it

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Men with subjective premature ejaculation have a similar lognormal IELT distribution as men in the general male population and differ mathematically from males with lifelong premature ejaculation after an IELT of 1.5 minutes (Part 2).

International journal of impotence research·2019
Same author

Use of a confirmed mathematical method for back-analysis of IELT distributions: ejaculation time differences between two continents and between continents and men with lifelong premature ejaculation (Part 1).

International journal of impotence research·2019
Same author

Differences between ICD-11 MMS and DSM-5 definition of premature ejaculation: a continuation of historical inadequacies and a source of serious misinterpretation by some European Regulatory Agencies (PART 2).

International journal of impotence research·2019
Same author

Method and design of drug treatment research of subjective premature ejaculation in men differs from that of lifelong premature ejaculation in males: proposal for a new objective measure (part 1).

International journal of impotence research·2019
Same author

Drug treatment options for premature ejaculation.

Expert opinion on pharmacotherapy·2018
Same author

Tramadol's Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats.

Frontiers in pharmacology·2018

Area of Science:

  • Immunology
  • Urology
  • Reproductive Medicine

Background:

  • Post Orgasmic Illness Syndrome (POIS) is a chronic, invalidating condition affecting men, characterized by immediate post-ejaculatory illness.
  • Symptoms vary in intensity and duration but are relatively constant for the individual, causing significant distress to patients and partners.
  • POIS is hypothesized to be an autoimmune disease, distinct from conditions associated with increased IgE levels.

Purpose of the Study:

  • To elucidate the underlying mechanisms and characteristics of Post Orgasmic Illness Syndrome (POIS).
  • To differentiate between primary and secondary POIS subtypes.
  • To identify potential antigens triggering the autoimmune reaction in POIS.

Main Methods:

  • Clinical observation and characterization of POIS symptoms into five criteria and seven clusters.
  • Analysis of serum IgE concentrations.
  • Indirect clinical evidence to identify the antigen involved in the autoimmune reaction.

Main Results:

  • POIS attacks occur within minutes to hours after ejaculation and resolve spontaneously within 3-7 days.
  • Total serum IgE concentrations are not elevated in POIS patients.
  • Evidence suggests the antigen triggering POIS is in seminal fluid, not spermatozoa, possibly originating from prostatic tissue.

Conclusions:

  • POIS is likely an autoimmune disorder triggered by seminal fluid components, not spermatozoa.
  • The condition affects both men and, rarely, women, with potential involvement of female prostatic tissue.
  • Further research is needed to confirm the autoimmune basis and identify specific triggers for effective treatment.
Keywords:
Post orgasmic illness syndrome (POIS)ejaculation

Related Experiment Videos