Related Experiment Video

Updated: Mar 14, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

9.7K

NBR2: A former junk gene emerges as a key player in tumor suppression

Zhen-Dong Xiao1, Xiaowen Liu1, Li Zhuang1

  • 1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.

Molecular & Cellular Oncology
|September 22, 2016
PubMed

Insights

Neighbor of BRCA1 gene 2 (NBR2) encodes a long non-coding RNA that suppresses tumor development. This occurs through the regulation of adenosine monophosphate-activated protein kinase (AMPK) activation, revealing NBR2's role in cancer biology.

Area of Science:

  • Genetics
  • Cancer Biology
  • Molecular Oncology

Background:

  • Neighbor of BRCA1 gene 2 (NBR2) is a non-protein coding gene located near the BRCA1 tumor suppressor.
  • The specific function of NBR2 in cancer development has not been previously elucidated.

Purpose of the Study:

  • To investigate the role of NBR2 in cancer biology.
  • To determine the molecular mechanism by which NBR2 influences tumor development.

Main Methods:

  • Gene expression analysis to confirm NBR2 encodes a long non-coding RNA.
  • Functional assays to assess the impact of NBR2 on tumor growth.
  • Biochemical studies to explore the regulatory pathway involving adenosine monophosphate-activated protein kinase (AMPK).

Main Results:

  • NBR2 was confirmed to encode a long non-coding RNA.
  • NBR2 demonstrates tumor-suppressive properties.
  • NBR2 regulates tumor development via the activation of adenosine monophosphate-activated protein kinase (AMPK).

Conclusions:

  • NBR2 functions as a long non-coding RNA with a suppressive role in tumor development.
  • The tumor-suppressive function of NBR2 is mediated by the regulation of AMPK activation.
  • NBR2 represents a potential novel target for cancer therapy.
Keywords:
AMPKBRCA1NBR2energy stress responselncRNAtumor suppression

More Related Videos

Inducible and Reversible Dominant-negative DN Protein Inhibition08:35

Inducible and Reversible Dominant-negative DN Protein Inhibition

Published on: January 7, 2019

8.8K
Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA108:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

15.1K

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

2.9K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.2K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

2.0K