Hydrocephalus and Ventriculoperitoneal Shunts: Modes of Failure and Opportunities for Improvement

Julianne Jorgensen1, Corin Williams2, Alisha Sarang-Sieminski1

  • 1Franklin W. Olin College of Engineering, Needham, Massachusetts, USA.

Insights

Hydrocephalus, an excess of brain fluid, is treated with ventriculoperitoneal (VP) shunts. This overview highlights VP shunt failures and opportunities for biomedical engineers and physicians to improve treatments for this condition.

Area of Science:

  • Biomedical Engineering
  • Neurosurgery
  • Pediatric Neurology

Background:

  • Hydrocephalus affects 0.5-4 per 1000 children, causing fluid buildup in brain ventricles.
  • Untreated hydrocephalus can lead to severe cognitive, visual, and neurological impairments, and death.
  • Current treatment involves ventriculoperitoneal (VP) shunts to drain cerebrospinal fluid (CSF).

Purpose of the Study:

  • To provide an overview of hydrocephalus and current VP shunt technology.
  • To detail the common complications and modes of failure associated with VP shunts.
  • To identify areas for collaboration between biomedical engineers and physicians to enhance shunt performance.

Main Methods:

  • Literature review of hydrocephalus and VP shunt technology.
  • Analysis of VP shunt complications including infection, obstruction, and malfunction.
  • Identification of research and development opportunities for improved shunt design and function.

Main Results:

  • VP shunts are the primary treatment but are prone to complications like infection, obstruction, and drainage issues.
  • Modifications to shunts and surgical techniques have yielded only modest improvements.
  • Numerous opportunities exist for innovation in shunt technology and collaborative research.

Conclusions:

  • VP shunt complications significantly impact patient outcomes.
  • Interdisciplinary collaboration is crucial for advancing hydrocephalus treatment.
  • Targeted engineering solutions can address current limitations in VP shunt efficacy and safety.

Related Concept Videos

Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
10.6K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.4K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
498