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Human salivary protein interaction with fluoridated synthetic hydroxyapatite
Journal De Biologie Buccale
|March 1, 1978
Summary
Fluoridation of hydroxyapatite significantly reduces salivary protein adsorption, suggesting it may decrease dental pellicle formation. This indicates a competitive interaction between salivary proteins and fluoride.
Area of Science:
- Biomaterials Science
- Dental Research
- Surface Chemistry
Background:
- Hydroxyapatite is a primary mineral component of teeth.
- Salivary proteins form the acquired pellicle on tooth surfaces.
- Fluoride application is a common dental caries prevention strategy.
Purpose of the Study:
- To investigate the effect of mineral phase fluoridation on human salivary protein adsorption onto synthetic hydroxyapatite.
- To understand the mechanism of interaction between fluoridated hydroxyapatite and salivary components.
- To assess the potential impact of fluoride on pellicle formation.
Main Methods:
- Utilized a previously described experimental system to test protein adsorption.
- Compared salivary protein adsorption on fluoridated hydroxyapatite versus untreated hydroxyapatite.
- Analyzed selective adsorption of calcium-precipitable human salivary glycoprotein.
- Monitored fluoride liberation influenced by salivary proteins.
Main Results:
- Adsorption of human salivary protein on fluoridated hydroxyapatite was substantially reduced compared to untreated hydroxyapatite.
- Calcium-precipitable human salivary glycoprotein demonstrated selective adsorption.
- Salivary proteins induced the liberation of fluoride from the mineral phase.
Conclusions:
- Fluoridation of hydroxyapatite significantly inhibits salivary protein adsorption.
- This inhibition may be attributed to a competitive adsorption effect between salivary proteins and fluoride.
- Fluoridation of dental enamel could reduce acquired pellicle formation, potentially impacting caries prevention strategies.