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Hypertension and arterial stiffness in heart transplantation patients

João David de Souza-Neto1, Ĺtalo Martins de Oliveira1, Hermano Alexandre Lima-Rocha2

  • 1Hospital de Messejana Dr. Carlos Alberto Studart Gomes, Unidade de Transplante e Insuficiência Cardíaca, Fortaleza/CE, Brazil.

Clinics (Sao Paulo, Brazil)
|September 23, 2016
PubMed

Insights

Post-transplantation hypertension is linked to arterial stiffness in heart transplant recipients. The ambulatory arterial stiffness index offers a new, non-invasive method to assess this cardiovascular risk factor.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Vascular Physiology

Background:

  • Post-transplantation hypertension is a common complication in heart transplant recipients.
  • It significantly increases the risk of cardiovascular events and impairs graft function.
  • Arterial stiffness is an emerging marker of cardiovascular risk.

Purpose of the Study:

  • To identify factors associated with arterial stiffness in adult heart transplant patients.
  • To evaluate the utility of the ambulatory arterial stiffness index (aASI) in this population.

Main Methods:

  • Prospective, observational, analytical study design.
  • Inclusion of 85 adult heart transplantation patients.
  • Ambulatory blood pressure monitoring to calculate aASI; multivariate logistic regression for analysis.

Main Results:

  • Hypertension was independently associated with arterial stiffness (OR 4.98).
  • Systolic and diastolic blood pressure averages and nighttime blood pressure descent were also linked to arterial stiffness.
  • The aASI demonstrated a significant association with hypertension in this cohort.

Conclusions:

  • The ambulatory arterial stiffness index is a novel, non-invasive tool for assessing arterial stiffness.
  • This index may improve the prognostic definition of arterial stiffness in heart transplant recipients.
  • Arterial stiffness, as measured by aASI, is associated with hypertension post-heart transplantation.
Abstract

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