FGF-23 and cardiovascular disease: review of literature

Area of Science:

• Endocrinology
• Cardiology
• Nephrology

Background:

• Fibroblast growth factor 23 (FGF-23) is a hormone primarily produced by bone cells.
• FGF-23 plays a crucial role in phosphate and vitamin D metabolism.
• Emerging evidence suggests FGF-23 may impact cardiovascular health.

Purpose of the Study:

• To review the current literature on the association between FGF-23 and cardiovascular disease.
• To synthesize findings on FGF-23's role in various cardiovascular conditions.

Main Methods:

• Systematic review of existing animal and human observational studies.
• Analysis of research investigating FGF-23 levels and cardiovascular outcomes.

Main Results:

• Elevated FGF-23 levels are associated with hypertension.
• Higher FGF-23 is linked to left ventricular hypertrophy and endothelial dysfunction.
• Increased FGF-23 is correlated with cardiovascular events and mortality.

Conclusions:

• A significant association exists between elevated FGF-23 and adverse cardiovascular outcomes.
• The precise mechanisms underlying FGF-23's cardiovascular effects require further elucidation.
• Clinical trials are necessary to ascertain if targeting FGF-23 can mitigate cardiovascular risk.