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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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What is the Skeletal System?01:02

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Overview
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Bone Density Loss Is Associated With Blood Cell Counts.

Rodrigo J Valderrábano1, Li-Yung Lui2, Jennifer Lee1,3

  • 1Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|September 23, 2016
PubMed
Summary

Declining bone mineral density (BMD) in older men is linked to changes in blood cell counts, including increased anemia and neutrophil levels, and decreased lymphocytes. This suggests a connection between bone health and the body's blood cell production.

Keywords:
ANALYSIS/QUANTITATION OF BONEBONE INTERACTORSDISEASES AND DISORDERS OF/RELATED TO BONEDXAOSTEOIMMUNOLOGYOSTEOPOROSIS

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Area of Science:

  • Gerontology
  • Hematology
  • Bone Biology

Background:

  • Osteoblasts, bone-forming cells, are known to influence blood cell development in preclinical models.
  • The impact of osteoblast function and bone mineral density (BMD) on human blood cell counts remains largely uncharacterized.

Purpose of the Study:

  • To investigate the association between BMD, BMD loss, and circulating blood cell counts in older men.
  • To test the hypothesis that lower BMD or greater BMD loss correlates with altered erythrocyte, lymphocyte, and myeloid cell levels.

Main Methods:

  • Cross-sectional and prospective analysis of 2571 community-dwelling men (age ≥65) from the Osteoporotic Fractures in Men (MrOS) study.
  • Multivariable-adjusted logistic regression analyzed associations between BMD (DXA scan), annualized BMD change, and high BMD loss with complete blood count (CBC) parameters, including white blood cell subtypes and anemia.

Main Results:

  • Greater total hip BMD loss was associated with increased odds of anemia, elevated neutrophils, and reduced lymphocytes.
  • Annualized BMD loss exceeding 0.5% at the femoral neck and total hip correlated with higher risks of anemia, neutrophilia, and lymphopenia.
  • Declining femoral neck BMD also showed associations with anemia and lower lymphocyte counts.

Conclusions:

  • Declining hip BMD over approximately seven years in older men is linked to increased risks of anemia, lower lymphocyte counts, and higher neutrophil counts.
  • These findings suggest a significant interdependency between bone health and hematopoiesis in humans, extending preclinical observations.
  • Maintaining bone health may be important for supporting healthy blood cell production in aging populations.