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Draft genome sequence of Acinetobacter pittii ST643 shared by cystic fibrosis patients

Géssica A Rocha1, Alex G Ferreira1, Danielle F Lima1

  • 1Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Microbiologia, Imunologia e Parasitologia, Rio de Janeiro, RJ, Brasil.

Memorias Do Instituto Oswaldo Cruz
|September 23, 2016
PubMed

Insights

Acinetobacter pittii, a hospital pathogen, was identified in Brazilian cystic fibrosis (CF) patients. This study presents the draft genome of this rare A. pittii sequence type (ST643) found in CF patients.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Acinetobacter pittii is a significant hospital-acquired pathogen.
  • Drug resistance and outbreaks are characteristic of A. pittii.
  • Acinetobacter species are infrequently detected in cystic fibrosis (CF) patients.

Purpose of the Study:

  • To describe the draft genome of Acinetobacter pittii sequence type ST643.
  • To investigate the presence of A. pittii ST643 in Brazilian cystic fibrosis patients.

Main Methods:

  • Isolation of Acinetobacter pittii ST643 from Brazilian CF patients.
  • Whole-genome sequencing and assembly of the A. pittii ST643 isolate.
  • Bioinformatic analysis of the draft genome.

Main Results:

  • Acinetobacter pittii sequence type ST643 was successfully isolated from multiple Brazilian CF patients.
  • The draft genome of A. pittii ST643 was generated and characterized.
  • This finding highlights a rare occurrence of A. pittii in the CF population.

Conclusions:

  • Acinetobacter pittii ST643 represents a potential emerging pathogen in cystic fibrosis care.
  • Genomic data of A. pittii ST643 can inform future research on its pathogenesis and treatment.
  • Further surveillance is warranted to understand the prevalence and impact of A. pittii in CF patients.

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